RAS bound with RASSF5, activate MST1/235,44 to form STK3/MST2 and STK4/MST1 complexes in the hippo signaling pathway that plays a crucial role in tumor suppression by limiting proliferation and stimulating apoptosis where SAV1, MOB1A/B act as effector molecules45,46. This evidence concerns the gene STK4 and neoplasm.