RASSF5 and cancer: Inactivation of RASSF5 has been found in several human cancers, such as lung cancer5, colorectal cancer5, gastric cancer34 etc. Changes in the structural conformation of RASSF5 protein during bio-molecular interactions play a vital role in executing its function35 but nsSNPs may cause aberrant conformations, which may lead to inactivation of its tumor suppressive properties36,37.