Such models allow for the simultaneous examination of a wide range of neuropathologies in specific brain regions, and has provided strong evidence that isocortical neurofibrillary tangles and lewy bodies are potently associated with low final MMSE scores10, and that the combination of vascular, amyloid, tau, neocortical Lewy body, and TAR DNA-binding protein 43 (TDP-43) pathology may account for all of the variance in risk of dementia diagnosis at death that was previously attributed to age9. The gene discussed is TARDBP; the disease is dementia.