Among these participants, 5,512 (58%) of 9,391 deceased participants had an autopsy, and 924 (17%) individuals with an autopsy had complete neuropathological data available for Alzheimer’s disease neuropathological change (ADNC), TDP-43 proteinopathy, Lewy bodies, and cerebral amyloid angiopathy (CAA). The gene discussed is TARDBP; the disease is early-onset autosomal dominant Alzheimer disease.