SREBF2 and bacterial infectious disease: It is widely acknowledged that cecal ligation and puncture (CLP) or lipopolysaccharide (LPS) induces systemic inflammation and overproduction of cytokines in C57BL/6N mice.52 We noticed that the bacterial infection induced not only cytokine storm, but also increased the levels of activated SREBP-2 and NF-κB, and mRNA levels of other related proteins (Fig. 5).