NLRP3 and Sepsis: The mRNA levels of nitrite/nitrate oxide (NOX), which is an indicator of sepsis, NLR family pyrin domain containing 3 (NLRP3) inflammasome, which plays a crucial role in innate immunity and inflammation,40 Il-1β, vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and SREBP-2 in mouse lung tissue were also maintained in low level in response to the inhibition of NF-κB signaling and SREBP-2 (Supplementary Fig. 7).