PLAUR is also known as UPAR, which reportedly plays an important role through the activation of latent growth factors, degradation of the extracellular matrix, and involvement in drug resistance.36 Besides, UPAR promoted tumor-permissive conditioning of macrophages and mediates T-cell suppression.37,38 This means that high UPAR may be related to chemoradiotherapy resistance. Here, PLAUR is linked to neoplasm.