CD19 and congenital rubella syndrome: CRS, the main toxicity of CAR T-cell therapy, is associated with a host of cardiac manifestations which may include tachycardia, decrease in EF and hypotension, among others.15 21 We report on the first pediatric study evaluating cardiotoxicity and its relationship to CRS in children and young adults who received a CD19-28ζ CAR construct.3 6 8