Given the prognostic role of immunophenotypic markers in CLL patients, the aim of study was to assess the association between expression of CD38, CD25, and double-positive CD56 and CD117 (ILC3s) markers with peripheral complete blood cell count (CBC) values in CLL patients, and staging as defined by different schemes and clinical parameters. This evidence concerns the gene CD38 and B-cell chronic lymphocytic leukemia.