Consequently, the development of immunity to malaria is increased, leading to significantly decreased malaria parasitemia, exacerbated malaria-induced liver immunopathology, accompanied with elevated expression levels of Gal-1 and Gal-3, increased activation of macrophages, neutrophils, and eosinophils and increased production of their mediators in co-infected mice. This evidence concerns the gene LGALS3 and malaria.