It has been reported that an eosinophilia is induced in P. falciparum malaria and the concentrations of eosinophil-derived granule proteins (ECP and EPX) are higher in patients with cerebral malaria than in uncomplicated cases or cases of severe malarial anemia, indicating eosinophil granule proteins are important in both the control of malaria infection and pathogenesis of severe malaria [50]. This evidence concerns the gene RNASE3 and malaria.