PICK1 and Alzheimer disease: Indeed, several studies have shown that GVBs and Pick bodies co-occur in the hippocampus of Pick’s disease cases, sometimes in the same neurons [74, 94, 99, 111, 118, 134], in the absence [111, 118, 134] or only low abundant presence [74] of AD-related NFTs, indicating a specific association of Pick’s type tau pathology with GVBs.