TARDBP and amyotrophic lateral sclerosis: Interestingly, GVBs were found to be more prevalent and more widely distributed in patients with TDP-43-related FTLD/ALS carrying a hexanucleotide repeat expansion in C9ORF72 (FTLD/ALS-C9) compared to TDP-43-related FTLD/ALS patients without a C9ORF72 repeat expansion and age-matched controls in an extensive study [113].