In addition to tauopathies, the presence of GVBs has been studied in the brains of patients with other neurodegenerative proteinopathies, including human prion diseases, α-synucleinopathies and TDP-43- and FUS-related FTLD and amyotrophic lateral sclerosis (ALS). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.