TNF and Hepatic fibrosis: The MSC secretome secreted some growth factors and cytokines, such as hepatocyte growth factor (HGF), transforming growth factor beta isoform 3 (TGF-β3), and tumor necrosis factor-alpha (TNF-α), and IL-10 can modulate cell signaling and processes involved in fibrogenesis and can attenuate liver fibrosis [5, 21].