To further ascertain that differential DNAm in lung cancer is enriched among SMAD2/3 targets and that this is happening preferentially in the endothelial compartment, we collated genome-wide ChIP-Seq binding intensity profiles for SMAD2/3 in endothelial cells and other cell types from the ChIP-Seq atlas resource [56]. The gene discussed is SMAD2; the disease is lung cancer.