Quantitative assessment by computer-assisted image analysis of immune cell densities (immunoreactive area (IRA%)) at the invasive margin of adenocarcinoma specimens revealed heterogenous distribution of the different cell types across patients, with median IRA% (IQR) respectively CD45RO-TILs 2.19 (2.14), CD8-TIL 0.42 (0.81), CD20-TILs 0.22 (0.51), CD20-TLT 2.84 (4.64), CD68-TAM 2.19 (1.56), IL17+ cells 0.39 (0.39), PD1-TILs 0.19 (0.41) (Fig. 2a). This evidence concerns the gene CD8A and adenocarcinoma.