CD8A and neoplasm: For the two lymphoid immune populations most relevant in prognostic studies performed in CRC, CD45RO-TILs and CD8-TILs, we analyzed whether there was a preferential localization at the invasive margin (IM) or tumor core (TC) and we found very similar values (Fig. 2d) and a significant concordance of the distribution in the two compartments (p = 0.002 and p = 0.004) (Fig. 2e, f).