Moreover, we also found that depleted SNHG17 markedly enhanced the sensitivity of LN-215 cells to temozolomide (TMZ), while miR-876-5p inhibition or ERLIN2 upregulation could reverse such sensitization effect (Supplementary Fig. 2A), indicating that SNHG17/miR-876-5p/ERLIN2 pathway might also work in the formation of TMZ-resistance in astrocytoma. This evidence concerns the gene ERLIN2 and astrocytoma (excluding glioblastoma).