HOTAIR and acute myeloid leukemia: The long noncoding RNAs have been uncovered to exert an pivotal influence on cell proliferation and apoptosis of AML, the mechanisms of which include altering methylation status of gene promoters [5, 6], recruiting epigenetic complex on gene promoters [26], reshaping chromatin [27, 28], sponging miRNAs to regulate gene expression [29–32], etc. HOTAIR is one of the most studied lncRNAs in AML, which is upregulated in de novo AML patients and predicts an adverse prognosis [33].