Macrophage-conditioned media was shown to prime IBC cells to be highly migratory, but this effect could be abrogated by RhoC GTPase knockout, indicating a role of RhoC GTPase in regulating the TME’s effect on IBC cells and further supporting RhoC as a potential therapeutic target for interventions to inhibit IBC metastasis. The gene discussed is RHOC; the disease is inflammatory breast carcinoma.