Over the antibody selection with the phage display libraries employed, the KFab-I library, an in house human synthetic Fab phage display library constructed on a VH3 and a Vk1 framework by randomizing their CDRs, yielded two anti-hYKL-40 mAb clones (H1 and H2) with high affinity of which H1 was selected dominantly (~73%) and found to be effective to inhibit growth and migration of cancer cells. Here, FANCB is linked to cancer.