NDUFB8 and neoplasm: In line with the marked increase in mitochondrial complex I under drug treatment observed in vitro (Figure 1 and Figure 2), tumor tissue from the anticancer drug-treated group showed approximately 5- (SNU-638) and 13-fold (A375) increases in expression of NADH dehydrogenase 1 beta subcomplex subunit 8 (NDUFB8) as a mitochondrial complex I compared with the untreated controls (Figure 6B).