Transcription factors such as Snail, Twist, Slug1, Zeb1, Zeb2, and FoxC2 reportedly activate EMT, which in turn is regulated by the TGFβ, Notch, Wnt, Hedgehog, NF-κB, and HIF-1 signaling pathways, all of which were implicated in a BCSC-driven therapy resistance and tumor progression [141,171,172,183]. This evidence concerns the gene HIF1A and neoplasm.