ALK and non-small cell lung carcinoma: In 1994, it was reported that the nucleophosmin ALK (NPM1-ALK) fusion gene was present on the t (2; 5) reciprocal translocation in anaplastic large cell malignant lymphoma, and in 2007, a fusion protein consisting of echinoderm microtubule-associated protein like-4 (EML4) and ALK was found in 6.7% of NSCLC patients [25].