CASP3 and colon carcinoma: For example, Al-Menhali et al. [95] registered moderate apoptotic capacity of aqueous extracts of T. vulgaris, which were shown to increase the activity of caspase 3/7 on human colon carcinoma cells HCT116 in a concentration-dependent manner (3.5%, 36.1% and 54.7% increase in the activity of caspase 3/7 in cells treated with 0.2, 0.4, or 0.6 mg/mL, respectively) [95].