Interestingly, mitophagy stimulation reduced tau hyperphosphorylation in vitro (SH-SY5Y cells overexpressing 2N4R, 1N4R, 2N3R tau) and in vivo (transgenic nematodes expressing human tau and 3xTgAD mice), and reversed memory impairment in transgenic animals [86]. This evidence concerns the gene MAPT and memory impairment.