In primary cultures of hippocampal neurons, the human 20–22 kDa NH2-tau fragment (NH2htau fragment mapping between 26 and 230 amino acids of the longest human tau isoform) was shown to increase mitophagic flux by recruiting Parkin to mitochondria, correlating with a decrease of synaptic stability [146,147], a feature also observed in human synaptic mitochondria from AD patients. Here, MAPT is linked to Alzheimer disease.