Xu et al. tested sulforaphane against skin carcinogenesis induced by the combined treatment of a chemical carcinogen, 7,12-dimethylbenz(a)anthracene (DMBA), and a tumor promoter, 12-O-Tetradecanoylphorbol-13-acetate (TPA) in Nrf2(-/-) knockout and wild type C57BL/6 mice [80]. Here, NFE2L2 is linked to neoplasm.