The transfer of cytosolic NADH into mitochondria in cancer cells requires the MAS, which is composed of two antiporters, the malate-α-KG antiporter (SLC25A11 or OGC) and the glutamate-aspartate antiporter (SLC25A12 or aspartate-glutamate carrier isoform 1), as well as glutamic-oxaloacetic transaminase 1 and 2 (GOT1 and 2), and malate dehydrogenase 1 and 2 [22,29]. The gene discussed is SLC25A11; the disease is cancer.