Indeed, Remillard et al. have identified 17 SNPs in iPAH patients and 12 SNPs have been identified in the 5′ untranslated region (UTR), 2 SNPs in the translated region of KCNA5, 2 SNPs in the 3′ UTR region, and 1 SNP in downstream KCNA5. Interestingly, the frequency of these two last SNPs in PAH patients with anorexigen history was significantly increased compared to in PAH patients without anorexigen history. The gene discussed is KCNA5; the disease is pulmonary arterial hypertension.