ABCC8 and pulmonary arterial hypertension: In addition, Kcnj11 mRNA expression is decreased in rat hearts and in H9c2 cells under hypoxia conditions [101].The reduction of ABCC8 expression in the RV from PAH patients and MCT-PH rats may contribute to abnormal PH-RV cardiomyocyte excitability, contractility, and metabolism [43].