PAH patients that carry KCNK3 mutations are younger at the time of diagnosis (median age of 28 years compared to 42 years for iPAH patients), and they have a higher mPAP (76 mmHg compared to 56.4 mmHg in iPAH patients) [18,56]. This evidence concerns the gene KCNK3 and idiopathic pulmonary arterial hypertension.