By combining in silico prediction with nuclear export assays, we report the identification of 19 novel sequence motifs with nuclear export activity in 14 proteins (SPN90, TFE3, SHIP2, PER1, SEPT6, SIR2, UBR5, FR1OP, AP2B1, IF2B, mTOR, CRTC1, CDC27 and ZO2, see Supplementary Figure S1) that belong to a putative “XPO1/CRM1-cancer exportome”. The gene discussed is SEPTIN6; the disease is cancer.