BARD1 and neoplasm: Furthermore, BAP1 interacts with a number of nuclear proteins, such as BRCA1 (Breast Cancer Type 1) and BARD1 (BRCA1-associated RING domain protein 1), and assembles an active multiprotein complex that promotes homologous recombination and double-strand break repair, thereby maintaining genomic stability and functioning as a tumor suppressor [37].