Although vitreous humor contains a high amount of TF in physiologic conditions both as the free form (apo-TF) and the iron-bound form (holo-TF) [31], the expression of TF and of its receptor is upregulated in retinal degeneration or inflammation [14,20,29] suggesting that TF levels could be a limiting factor in disease conditions. Here, TF is linked to retinal degeneration.