However, caution should be taken because, although ACE1 inhibitors (such as captopril, enalapril, and lisinopril) and angiotensin II receptor blockers (ARB) (such as olmesartan, losartan, candesartan, and valsartan) do have inhibitory effects on ACE2 [91], several studies showed that these drugs can increase the ACE2 blood level [86], which will likely increase the risk of contracting SARS [92]. The gene discussed is ACE2; the disease is severe acute respiratory syndrome.