COL1A1 and metabolic dysfunction-associated steatohepatitis: Moreover, vitE has been suggested to affect key cellular pathways in NASH by regulating the expression of target genes involved in the formation of steatosis (HMG-CoA reductase, a low-density lipoprotein receptor and scavenger receptor cluster of differentiation 36), inflammation (I-2, IL-4, IL-1β and nuclear factor-κΒ) and fibrosis (TGF-β, collagen 1a1 (Col1a1) and matrix metalloproteinases) [20,30,32,33].