ACTA1 and metabolic dysfunction-associated steatohepatitis: qPCR expression analyses showed a significant decrease in inflammatory (IL-8 and monocyte chemotactic protein 1 (MCP-1)) and fibrotic target genes (TGF-β, α smooth muscle actin (α-sma) and Col1a1) in NASH animals subjected to vitE supplementation and diet change (low fat, no cholesterol), compared to a dietary intervention alone [20].