The study showed that vitE combined with life style modification recommendations (dietary modification, weight loss and exercise) has the ability to improve overall NASH, lowering liver injury enzymes (ALT and AST), and significantly improving hepatic steatosis, lobular inflammation and ballooning hepatocytes, although with no significant effect on fibrosis [20,26,45]. This evidence concerns the gene GPT and metabolic dysfunction-associated steatohepatitis.