KDR and lung cancer: Furthermore, βTrCP was found to be associated with lung cancer by ubiquitinating its one of the targets, FOXN2 (Forkhead box transcription factor), which plays a role in cell proliferation and radiosensitivity in lung cancer [57] Additionally, it was shown that βTRCP stimulates the ubiquitination and degradation of VEGF (Vascular Endothelial Growth Factor) receptor 2, thereby inhibiting angiogenesis and the migration of papillary thyroid cancer cells [58].