Relatively, in chronic myelogenous leukemia (CML), the deletion of FBW7 enhances the expression of c-Myc; it also leads p53-dependent apoptosis in human leukemia-initiating cell (LIC), and eventually, tumorigenesis is inhibited [40]. Here, FBXW7 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.