FBW7 was also associated with the mTOR pathway, in such a way that mTORC2 inhibition induces lipogenesis through the FBW7-mediated degradation of sterol regulatory element-binding protein 1 (SREBP1), which in turn decelerates tumor progression in lung, thyroid, melanoma, and cervical cancer [42]. This evidence concerns the gene SREBF1 and melanoma.