Knocking down Smad3 in lnc-TSI knockout Caki-1 cells abrogated the migration and invasion abilities enhanced by lnc-TSI knockout, indicating that the function of lnc-TSI on the migration and invasion of ccRCC cells depended on Smad3 (Figures 5E and 5F). Here, SMAD3 is linked to nonpapillary renal cell carcinoma.