MBOAT7 was a potentially interesting target as an enzyme involved in (phospho)lipid metabolism, conceptually similar to other SNVs at GWAS significance in alcoholic and non-alcoholic liver disease, namely TM6SF2 and PNPLA3. Later studies found the variant to influence the full spectrum of fatty liver disease, from steatosis to NASH, to fibrosis, cirrhosis, and HCC.5 This evidence concerns the gene TM6SF2 and hepatocellular carcinoma.