Additionally, a polymorphism in LHCGR that increase its activity was previously associated with decreased survival in men, a few reports have found LHCGR expression and LH-activity in PCa derived cell lines, and expression of hCG in prostate tumors has been associated with poor prognosis, which all supports a role for LHCGR in PCa progression [13–16]. Here, LHCGR is linked to prostate neoplasm.