LHCGR and posterior cortical atrophy: We also tested the LHCGR antibodies on normal testis and PCa tissue specimens by IHC, which showed a specific membranous/cytoplasmic Leydig cell specific expression in the testis, while in human PCa tissue LHCGR was expressed in cytoplasm of the PCa cells and in the cytoplasm of all investigated cell lines (Fig 1C, S3 Fig).