Furthermore, analysis of gene expression in 23 human melanoma cell lines as well as in normal human epidermal melanocytes (NHEM) using a microarray platform revealed that the expression of TFEB and TFE3 was roughly 50-fold lower than that of MITF, whereas expression of TFEC mRNA was about 850-fold lower than that of MITF [21,31]. This evidence concerns the gene TFEC and melanoma.