STK11 mutations are associated with an “immune cold” tumor microenvironment characterized by low or no PD-L1, low T-cell densities, high levels of granulocyte colony stimulating factor and IL-8 family cytokines, high density of neutrophil-like cells, and production of myeloid cell-recruiting chemokines such as IL-6 [19, 31, 32]. Here, CD274 is linked to neoplasm.