CXCL8 and inflammation: Interaction with its CD40 receptor induces the production of several potent proinflammatory cytokines, such as IL-1, IL-6, and IL-8 [22], thereby facilitating the development of acute coronary syndrome [21], activation of the NF-kappa β pathway [23], and phosphorylation of KKI (Kappa β kinase inhibitor), which in turn trigger the genes involved in cardiac inflammation and hypertrophy [3].