Ectrodactyly‐ectodermal dysplasia‐clefting syndrome 3 (EEC) is one of at least six overlapping syndromes caused by mutations in the tumor protein p63 gene (TP63) (Rinne, Hamel, van Bokhoven, & Brunner, 2006). The gene discussed is TP63; the disease is exstrophy-epispadias complex.