Whole exome sequencing (WES) revealed a de novo heterozygous pathogenic variant in the TP63 gene: p.His247Arg: c.740A>G (NM_003722.4), which has been reported with ectrodactyly‐ectodermal dysplasia‐clefting syndrome 3 (EEC), both with and without orofacial clefting. The gene discussed is TP63; the disease is exstrophy-epispadias complex.