In summary, the QSYQ compound could inhibit excessive myocardial autophagy by regulating the PI3K/Akt‐mTOR pathway to exert an effect on reparative myocardial fibrosis and can be a potential therapeutic approach to treat the cardiovascular diseases such as myocarditis and dilated cardiomyopathy. This evidence concerns the gene AKT1 and dilated cardiomyopathy.