Wright used the panel of P450 ABPP probes 1–6 to investigate the effect of high‐fat diet‐induced obesity on the P450 activities in the liver and lungs of mice.[30] Their data showed significantly reduced activities of hepatic P450s in obese mice, which also led to a decreased capacity for bile acid synthesis. Here, CYP2B6 is linked to obesity due to melanocortin 4 receptor deficiency.