Cdkl5 KO mouse models of CDD have been generated and recapitulate some phenotypic features observed in patients such as hyperexcitability and deficits in social interaction, vision, motor control and memory (Amendola et al., 2014; Okuda et al., 2018; Wang et al., 2012). Here, CDKL5 is linked to craniodiaphyseal dysplasia.