MECP2 and Rett syndrome: For modelling Rett syndrome, several mouse models expressing different types of MECP2 mutations are currently available, including truncated (Mecp2 R168X and R255X) and missense mutations (Mecp2 T158A, T158M, Y120D and R306C) found in patients (Bertoldi et al., 2019; Gandaglia et al., 2019; Goffin et al., 2011; Guy, Hendrich, Holmes, Martin, & Bird, 2001; Katz et al., 2012; Lyst et al., 2013; McLeod et al., 2013).