Furthermore, in an interim analysis of an ongoing multicentre, randomised, double-blinded, placebo-controlled trial, the FXR agonist obeticholic acid (25 mg) improved fibrosis and non-alcoholic steatohepatitis (NASH) disease activity in 23% of participants with F1–F3 fibrosis assessed by histological scoring. The gene discussed is NR1H4; the disease is metabolic dysfunction-associated steatohepatitis.