On the basis of univariate Cox analysis, a total of eight genes were closely related to the prognosis of ovarian cancer patients: ENPP1, FH, CYP2E1, HPGDS, ADCY9, NDUFA5, ADH1B and PYGB. Further analysis helped us to distinguish high-risk and low-risk groups to develop the metabolism-based prognostic index. This evidence concerns the gene ENPP1 and ovarian cancer.