For example, KLF5 binds to a CCNE1 promoter proximal element in bladder cancer cells (Pattison et al., 2016) and KLF5 increases the expression of Ccnb1 and Mcm2 downstream of oncogenic Ras in fibroblasts (Nandan et al., 2005). This evidence concerns the gene CCNE1 and urinary bladder cancer.