But other studies failed to confirm this association.11, 13Nikpour et al reported that in Iranian children and adolescents, −286C > A > T CRP polymorphism (rs3091244) is not associated with the increased risk for MetS.13Furthermore, Gaysina et al did not find association between CRP gene variants rs1205 and rs3093068 with the metabolic syndrome in U.K. population.11 The gene discussed is CRP; the disease is metabolic syndrome.