ANGPT1 and renal fibrosis: It can convert angiotensin I (AngI) to angiotensin 1–9 (Ang 1–9) and angiotensin II (Ang II) to angiotensin 1–7 (ANG 1–7) to decrease AngII, which can increase aldosterone and vasopressin secretion, cause vasoconstriction, and induce myocardial and renal fibrosis (Flores-Muñoz et al., 2011; Serfozo et al., 2020).