ACE2 is reported to improve acute lung injury, suppress hypertension and cardiac dysfunction, reduce glomerular and biliary fibrosis, stimulate brown adipose tissue and induce browning in white adipose tissue (Minato et al., 2020; Liu et al., 2020; Rajapaksha et al., 2019; Kawabe et al., 2019; Chen et al., 2019). This evidence concerns the gene ACE2 and hypertensive disorder.