SLIT2 and choroidal neovascularization: ,18 Slit homolog 2 (SLIT2) is a ligand for ROBO receptors regulating axonal growth, and SLIT2–ROBO4 signaling inhibits the VEGF-induced migration, tube formation, and permeability of endothelial cells in vitro and suppresses neovascularization and vascular leakage in the mouse models of retinal neovascularization and choroidal neovascularization (CNV).15