But analysis of NRF2 expression based on patient's genotype demonstrated that DFU (2-fold, p < 0.0001), T2DM (1.1-fold, p < 0.0001), and NGT (1-fold, p < 0.001) subjects with the homozygous mutant TT genotype had a greater decline in NRF2 expression when compared to T2DM and DFU subjects with homozygous wild CC genotype. Here, NFE2L2 is linked to type 2 diabetes mellitus.