IL10 and type 2 diabetes mellitus: As depicted in Figure 4, DFU subjects with the homozygous mutant TT genotype were observed to have a significant increase in IL-6 and TNF-α expression when compared to T2DM and DFU subjects with homozygous wild CC genotype, whereas IL-10 expression was significantly decreased in DFU subjects with the homozygous mutant TT genotype when compared to T2DM and DFU subjects with homozygous wild CC genotype.