Our investigation demonstrated that the rs35652124 TT genotype was significantly associated with T2DM and DFU and found to have a significant decrease in transcriptional levels of NRF2 and anti-inflammatory marker IL-10 and a significant increase in pro-inflammatory markers TNF-α and IL-6, suggesting the inherent deleterious impacts of the polymorphism. Here, TNF is linked to type 2 diabetes mellitus.