PDE5A and Alzheimer disease: In addition, cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), NADPH oxidase (NOX), lipoxygenase (LOX), c-Jun N-terminal kinase 3 (JNK-3), protein tyrosine phosphatase 1B (PTP1B), phosphodiesterase type 5 (PDE5), NADPH oxidase, sodium-glucose cotransporter (SGLT)1, SGLT2, and DJ-1 have been associated with the expression of anti-inflammatory mediators, neuroprotection, and ROS regulation and therefore represent promising AD targets [21–29].