Given that BRAF-VE1 IHC in CNS tumor samples should be used in conjunction with molecular analysis, and that, as mentioned above, a conventional direct sequencing has a limited power in some of these samples, we decided to verify whether the Idylla BRAF mutation assay performed on the fully automated Idylla platform may be a useful tool to accurately predict BRAF mutation status in GG and PA. This evidence concerns the gene BRAF and central nervous system neoplasm.