In the present study, protein expression of GSK-3β and P-GSK-3β (Tyr216) was activated, while P-GSK-3β (Ser9) and β-catenin were inhibited in the PD model group with α-syn transferred, which was consistent with the previous study, and CFR administration significantly inhibited the overexpression of α-syn, GSK-3β, and P-GSK-3β (Tyr216) and also increased the protein expression of P-GSK-3β (Ser9) and β-catenin. This evidence concerns the gene GSK3B and Parkinson disease.