GSK3B and Parkinson disease: As the in vivo study indicated, CFR attenuated the α-syn-induced PD rat behaviors with the rotation numbers decreased significantly and inhibited the cell apoptosis in the substantia nigra and striatum tissues of the PD rat brain; the overexpression of α-syn was inhibited, and the protein expression of GSK-3β, P-GSK-3β (Ser9), P-GSK-3β (Tyr216), and β-catenin in the GSK-3β/β-catenin signaling pathway was also regulated by CFR administration.