While FO supplement decreased these pro-inflammatory factors induced by ethanol feeding, but did not rescue hepatic IL-10 (Fig. 2a, b), we speculated that the inhibition of pro-inflammatory factors, but not normalization of anti-inflammatory cytokines, contribute to the protective effects of FO against alcoholic hepatic inflammation in the mouse model of chronic-plus-single-binge ethanol feeding. Here, IL10 is linked to inflammatory response.